Allergic Reactions to Metamizole: Immediate and Delayed Responses

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Allergic Reactions to Metamizole: Immediate and Delayed Responses.

BACKGROUND Pyrazolones are the most common causes of selective nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity. We studied a large group of patients with immediate and delayed selective responses to metamizole. METHODS Patients with suspicion of hypersensitivity to metamizole were evaluated. We verified acetylsalicylic acid tolerance and classified patients as immediate or delaye...

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Nonredundant Roles for Basophils in Immediate- and Delayed-onset Allergic Reactions

Basophils circulate in the peripheral blood under physiological conditions, and they are recruited to affected tissues in allergic reactions, albeit in small numbers. Because of their rarity (less than 1% of peripheral blood leukocytes are basophils), and their similarity to mast cells, basophils have often been considered the lesser relatives of mast cells. Moreover, because basophils have bee...

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Patch testing in the investigation of non-immediate cutaneous adverse drug reactions to metamizole.

Metamizole [INN; dipyrone (BAN, USAN)] is a pyrazolone derivative and one of the most commonly prescribed analgesics worldwide (1). Along with non-steroidal anti-inflammatory drugs (NSAIDs), metamizole is very frequently involved in hypersensitivity reactions (2). Immunologically mediated hypersensitivity reactions to metamizole can be immediate (IgE-mediated) or non-immediate (T cell-mediated)...

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ژورنال

عنوان ژورنال: International Archives of Allergy and Immunology

سال: 2016

ISSN: 1018-2438,1423-0097

DOI: 10.1159/000444798